Retatrutide results: Clinical trial results so far
Retatrutide is one of the latest weight loss medications, but it’s still in clinical trials which means it has not yet been approved for use or prescription, in the UK or elsewhere.
Early retatrutide results are promising – some results show up to 24.2% weight loss in the first 48 weeks. While it may be tempting to try and access this drug before it’s approved, it can be incredibly dangerous to buy retatrutide online – the long-term side effects are unknown and any suppliers are unregulated.
But alternative support is available. If you’re living with overweight or obesity and seeking professional support and weight loss medication, Oviva could help.
Key Takeaways
- Retatrutide is a weight loss medication that is currently undergoing clinical testing.
- It supports weight loss by curbing appetite, burning fat, regulating blood glucose, and slowing digestion – designed to be combined with lifestyle changes.
- Retatrutide produced up to 24.2% weight loss over 48 weeks during trials at the highest dose.
- Attempting to buy retatrutide online is dangerous – long-term side effects are unknown and there’s a risk of receiving counterfeit products with toxic ingredients.
What are the latest retatrutide trial results?
Retatrutide is still in clinical trials to better understand its safety and how effective it is for weight loss.
In phase 2 of the trails, Retatrutide produced weight loss results of up to 24.2% of body weight after 48 weeks.
83% of participants who received the maximum dose (12 mg) lost 15% or more of their body weight. And all patients receiving at least an 8 mg dose achieved a 5% weight loss or more.
Retatrutide weight loss results varied based on the dose:
| Retatrutide dose | Average weight loss after 48 weeks |
| 1 mg | 8.7% |
| 4 mg | 17.1% |
| 8 mg | 22.8% |
| 12 mg | 24.2% |
The study also showed early evidence that retatrutide can support healthier:
- Cholesterol
- Blood pressure
- Blood glucose
- Liver fat
If you find anecdotal reports online that highlight even faster results, please know these aren’t verified by experts, are not medically-supervised results and may not reflect trial data.
How does retatrutide help with weight loss?
Retatrutide is a triple hormone agonist, meaning it mimics three hormones in the body:
- GLP-1
- GIP
- Glucagon
These hormones are responsible for things like appetite, cravings and blood sugar levels. So, by mimicking these hormones, retatrutide can:
- Suppress your appetite
- Slow digestion
- Regulate your blood glucose levels
- Boost your body’s ability to burn fat
What other benefits are being studied?
Early clinical trials have explored more of retatrutide’s potential benefits, like improving:
- Blood glucose
- Blood pressure
- Triglycerides
- Cholesterol
- Liver fat
- Insulin
NALFD
Liver fat content was reduced in participants with non-alcoholic fatty liver disease (NAFLD) more than a placebo. And this was true for all doses.
In fact, in phase 2 trials, NAFLD was reversed for over 85% of participants on an 8 mg or 12 mg dose.
Some users report energy and mood improvements, as well as reduced inflammation and pain. But these findings are still under review, and further research is needed.
For the first time I’ve found something that truly works. I’m eating about two thirds of what I ate before, making healthier choices and I genuinely can’t stomach a lot of rich or sweet foods now. It’s given me the boost I needed, without the extreme of surgery.
Retatrutide vs. tirzepatide: is it more effective?
Retatrutide peptide results to date show weight loss results of up to 24.2% of body weight after 48 weeks.
Clinical trials for tirzepatide, the active ingredient in Mounjaro, show weight loss results of up to 22.5% after 72 weeks.
While that may initially make retatrutide seem more effective than tirzepatide, there are no direct comparison trials yet. These studies had different participants and different timelines, so further research is needed before concrete conclusions can be drawn.
Read more: Retatrutide vs. tirzepatide: how they’re different
Is retatrutide available in the UK?
No – retatrutide is not yet available in the UK.
Retatrutide is currently in phase 3 of clinical trials. The retatrutide phase 3 results won’t be published until early 2026, and approval won’t be decided until these results are back.
Buying retatrutide online or via unregulated suppliers is unsafe and can pose serious health risks. Like with the dangers of buying Mounjaro online, there’s a risk of counterfeit products, which could contain toxic ingredients.
People have been hospitalised in the UK after buying weight loss medications from unapproved suppliers. And as retatrutide hasn’t been fully studied, the long-term side effects are unknown.
Weight loss medication should only be taken if you meet eligible medical criteria, and it’s vital to be medically supervised throughout your treatment to support the dosing schedule and any side effects.
Safe, effective alternatives are already available
While retatrutide is still awaiting approval as a weight loss medication in the UK, effective alternatives are already available.
If you’re eligible, you could access approved weight loss medication and a personlised weight loss plan from Oviva – all funded by the NHS.
With Oviva, you’ll enjoy:
- A tailored weight loss plan, backed by science
- Remote support from doctors, dietitians and coaches
- Easy tracking for meals, goals, activities and more with the Oviva app
- And you may be eligible for weight loss medication delivered to your door
Never count calories again
Easily log your meals with the photo diary in the Oviva app – a simple way to keep track of what you’re eating.
Set goals that feel right
Your health coach will help you set the right personal goals that bring you closer to your feel-good weight.
Keep track of your progress
With your unique goals set, the Oviva app has all the tracking you need to work towards them with ease.
Become an expert yourself
With learning content on nutrition, exercise, and motivation, you’ll become a weight-loss expert yourself.
Always there to support
Get 1-to-1 support from a health coach and chat with our nutrition experts anytime via the Oviva app.
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